Expression of heat shock proteins (Hsps) 27 and 70 in kidney in cases of fatal hemorrhage.

E Doberentz, A Wegner, L Rochlitzer, B Madea, J Ulbricht

Forensic science international 2022 Jul

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The expression levels of intracellular heat shock proteins (Hsps), specialized chaperone proteins, increase in cases of cellular stress with protein misfolding and aggregation. In a previous study, we demonstrated that there is an extensive increase in intracellular Hsp27 and 70 expression levels in renal tissues in fire fatality cases. Hsp expression can be induced by not only heat, but also by tissue hypoxia. In cases of fatal hemorrhage, the individual suffers hypoxemia and consequently tissue hypoxia. Here, we examined 43 cases of fatal hemorrhage and a control group of 85 deaths not related to blood loss or temperature exposure. We evaluated Hsp27 and 70 protein expression levels in renal tissue using immunohistochemistry. The results revealed that no extensive Hsp27 or 70 expression is induced in the fatal hemorrhage cases. The renal Hsp levels were similar to those of the control group. Fatal blood loss does not cause relevant cell stress. Copyright © 2022 Elsevier B.V. All rights reserved.

Citation

E Doberentz, A Wegner, L Rochlitzer, B Madea, J Ulbricht. Expression of heat shock proteins (Hsps) 27 and 70 in kidney in cases of fatal hemorrhage. Forensic science international. 2022 Jul;336:111316