Plin5, a New Target in Diabetic Cardiomyopathy.

Xiangning Cui, Jingwu Wang, Yang Zhang, Jianliang Wei, Yan Wang

Oxidative medicine and cellular longevity 2022

filter terms:

Abnormal lipid accumulation is commonly observed in diabetic cardiomyopathy (DC), which can create a lipotoxic microenvironment and damage cardiomyocytes. Lipid toxicity is an important pathogenic factor due to abnormal lipid accumulation in DC. As a lipid droplet (LD) decomposition barrier, Plin5 can protect LDs from lipase decomposition and regulate lipid metabolism, which is involved in the occurrence and development of cardiovascular diseases. In recent years, studies have shown that Plin5 expression is involved in the pathogenesis of DC lipid toxicity, such as oxidative stress, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and insulin resistance (IR) and has become a key target of DC research. Therefore, understanding the relationship between Plin5 and DC progression as well as the mechanism of this process is crucial for developing new therapeutic approaches and exploring new therapeutic targets. This review is aimed at exploring the latest findings and roles of Plin5 in lipid metabolism and DC-related pathogenesis, to explore possible clinical intervention approaches. Copyright © 2022 Xiangning Cui et al.

Citation

Xiangning Cui, Jingwu Wang, Yang Zhang, Jianliang Wei, Yan Wang. Plin5, a New Target in Diabetic Cardiomyopathy. Oxidative medicine and cellular longevity. 2022;2022:2122856