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The diminished ability for muscle to regenerate is associated with aging, diabetes, and cancers. Muscle regeneration depends on the activation and differentiation of satellite cells (SCs). Inactivation of Mst1/2 promotes cell proliferation by activating Yap, and that has been reported as a potential therapeutic target for improving many organ regeneration. However, the function of Mst1/2 in SCs fate decision and that effect on muscle regeneration remain unknown. By using inducible conditional knockout Mst1/2 in the SCs of mice and an inhibitor of Mst1/2, we found that inhibition of Mst1/2 in SCs significantly decrease Yap phosphorylation, thus causing Yap to accumulate in the nucleus and impairing SC differentiation; Mst1/2 were slightly elevated by irisin stimulation during SC differentiation; but inhibiting Mst1/2 in SCs significantly impaired irisin-induced muscle regeneration. These results indicate that Mst1/2 is necessary for SC differentiation and inhibiting Mst1/2 as a therapeutic target has potential risks for muscle regeneration. © The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please email:


Jingjing Yang, Kezhi Wang, Yina An, Ran Wu, Jiangbo Li, Haidong Wang, Yanjun Dong. Mst1/2 Is Necessary for Satellite Cell Differentiation to Promote Muscle Regeneration. Stem cells (Dayton, Ohio). 2022 Mar 03;40(1):74-87

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PMID: 35511870

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