Ni-catalysed deamidative fluorination of amides with electrophilic fluorinating reagents.

Feng-Wei Wu, Yang-Jie Mao, Jun Pu, Huan-Le Li, Peng Ye, Zhen-Yuan Xu, Shao-Jie Lou, Dan-Qian Xu

Organic & biomolecular chemistry 2022 May 26

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We describe here a Ni-catalysed deamidative fluorination of diverse amides with electrophilic fluorinating reagents. Different types of amides including aromatic amides and olefinic amides were well compatible, affording the corresponding acyl fluorides in good to excellent yields.

Citation

Feng-Wei Wu, Yang-Jie Mao, Jun Pu, Huan-Le Li, Peng Ye, Zhen-Yuan Xu, Shao-Jie Lou, Dan-Qian Xu. Ni-catalysed deamidative fluorination of amides with electrophilic fluorinating reagents. Organic & biomolecular chemistry. 2022 May 26;20(20):4091-4095