Practical method for hydroxyl-group protection using strontium metal and readily available silyl chlorides.

We have found that the etherification of silyl-protected secondary alcohols proceeds smoothly in the presence of strontium metal using silyl chloride instead of the expensive, yet more reactive, and commonly used silyl triflate. The reaction occurred almost completely with various alcohols.

Citation

Norikazu Miyoshi, Aki Miyoshi, Yasuaki Miyazaki, Shigeki Kubo, Masaharu Ueno. Practical method for hydroxyl-group protection using strontium metal and readily available silyl chlorides. Chemical communications (Cambridge, England). 2022 May 26;58(43):6312-6315

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PMID: 35522074

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