Chemical synthesis of polysaccharides.

Shengyang Wang, You Yang, Qian Zhu, Guo-Qiang Lin, Biao Yu

Current opinion in chemical biology 2022 Aug

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Here we summarize the chemical syntheses of glycans containing over 20 monosaccharide units, with the recent syntheses of ultra-long glycans, including a 92mer arabinogalactan, a 100mer and a 151mer mannan, and a 128mer rhamnomannan, being highlighted. The assembly strategies, glycosylation methods, and protecting group manipulations, which are crucial to the successful synthesis, are discussed to give guidance for the future synthesis of various polysaccharides. Copyright © 2022. Published by Elsevier Ltd.

Citation

Shengyang Wang, You Yang, Qian Zhu, Guo-Qiang Lin, Biao Yu. Chemical synthesis of polysaccharides. Current opinion in chemical biology. 2022 Aug;69:102154