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Protein transport is an interesting and intrinsic life feature that is highly relevant to physiology and disease in living beings. Herein, inspired by nature, based on the supramolecular host-guest interaction, we have introduced the classical azobenzene light switches and L-phenylalanine derived pillar[6]arene (L-Phe-P6) into the artificial nanochannel to construct light-responsive nanochannels that could regulate protein transport effectively under the control of ultraviolet (UV) and visible (Vis) light. The light-controlled distribution of L-Phe-P6 in the channel led to the difference in surface charges in the nanochannel, which eventually brought the difference in protein transport. This research may not only provide a convenient theoretical model for biological research, but also a flexible light-responsive protein transport model, which will play a crucial role in light-controlled release of protein drugs and so on. © 2022 Wiley-VCH GmbH.


Lei Yang, Fan Zhang, Chunxiu Chen, Zhisheng Liu, Lu Liu, Haibing Li. Ultraviolet/Visible Light Regulated Protein Transport Gate Constructed by Pillar[6]arene-based Host-Guest System. Chemistry, an Asian journal. 2022 Jul 15;17(14):e202200455

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PMID: 35532204

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