Lei Yang, Fan Zhang, Chunxiu Chen, Zhisheng Liu, Lu Liu, Haibing Li
Chemistry, an Asian journal 2022 Jul 15Protein transport is an interesting and intrinsic life feature that is highly relevant to physiology and disease in living beings. Herein, inspired by nature, based on the supramolecular host-guest interaction, we have introduced the classical azobenzene light switches and L-phenylalanine derived pillar[6]arene (L-Phe-P6) into the artificial nanochannel to construct light-responsive nanochannels that could regulate protein transport effectively under the control of ultraviolet (UV) and visible (Vis) light. The light-controlled distribution of L-Phe-P6 in the channel led to the difference in surface charges in the nanochannel, which eventually brought the difference in protein transport. This research may not only provide a convenient theoretical model for biological research, but also a flexible light-responsive protein transport model, which will play a crucial role in light-controlled release of protein drugs and so on. © 2022 Wiley-VCH GmbH.
Lei Yang, Fan Zhang, Chunxiu Chen, Zhisheng Liu, Lu Liu, Haibing Li. Ultraviolet/Visible Light Regulated Protein Transport Gate Constructed by Pillar[6]arene-based Host-Guest System. Chemistry, an Asian journal. 2022 Jul 15;17(14):e202200455
PMID: 35532204
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