Physiological Functions of FBW7 in Metabolism.

Jianmei Zhang, De-Huan Kong, Xiaocheng Huang, Rongbo Yu, Yachao Yang

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2022 May

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FBW7 is the recognition subunit of the SCF (Skp1-Cullin1-F-box proteins) E3 ubiquitin ligase complex, and it determines the specificity of the SCF substrate. SCFFBW7 is a recognized tumor suppressor because of its ability to degrade many proto-oncogenic substrates. Recent studies have shown that FBW7 plays a key role in metabolism by targeting the degradation of critical regulators involved in cellular metabolism in a ubiquitin-dependent manner. Here, we review recent studies, which highlight the important role of FBW7 in metabolism. Thieme. All rights reserved.

Citation

Jianmei Zhang, De-Huan Kong, Xiaocheng Huang, Rongbo Yu, Yachao Yang. Physiological Functions of FBW7 in Metabolism. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2022 May;54(5):280-287