Elongator regulates the melanocortin satiety pathway.

Joseph Walters, Cody Walters, BreAnna Cameron, Lynn George

Biochemical and biophysical research communications 2022 Jul 12

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This study investigates the function of Elp1 and Elongator in the pituitary gland. Two conditional knockout models were generated where Elp1 was selectively deleted in either somatotropes of the anterior pituitary or Pomc-expressing cells of the anterior and intermediate pituitary. Although loss of Elp1 in somatotropes did not significantly impact murine growth or development, its loss in Pomc-expressing cells resulted in dramatically reduced levels of α-MSH, hyperphagia and obesity. This report provides the first evidence that Elongator plays an essential role in regulating the melanocortin satiety pathway. Copyright © 2022 Elsevier Inc. All rights reserved.

Citation

Joseph Walters, Cody Walters, BreAnna Cameron, Lynn George. Elongator regulates the melanocortin satiety pathway. Biochemical and biophysical research communications. 2022 Jul 12;613:73-80