Correlation Engine 2.0
Clear Search sequence regions

  • boron (2)
  • boron- compounds (6)
  • catalysis (1)
  • copper (3)
  • Sizes of these terms reflect their relevance to your search.

    Compared with the well-developed carbon-stereogenic chemistry, the construction of boron-stereogenic compounds remains undeveloped and challenging. Herein, the previously elusive catalytic enantioselective construction of boron-stereogenic compounds has been achieved through enantioselective desymmetric B-H bond insertion reaction. The B-H bond insertion reaction of 2-arylpyridine-boranes with versatile diazo compounds under chiral copper catalyst can afford boron-stereogenic compounds with good to excellent enantioselectivity. Moreover, the synthetic utility of this reaction is demonstrated by the scalability and downstream transformations. DFT calculations provide insights into the reaction mechanism and the origin of stereoselectivity. © 2022. The Author(s).


    Guan Zhang, Zhihan Zhang, Mengyuan Hou, Xinping Cai, Kai Yang, Peiyuan Yu, Qiuling Song. Construction of boron-stereogenic compounds via enantioselective Cu-catalyzed desymmetric B-H bond insertion reaction. Nature communications. 2022 May 12;13(1):2624

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 35552397

    View Full Text