Overview: Themes in Innate Lymphoid Cell Biology.

Marco Colonna

Advances in experimental medicine and biology 2022

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Since their initial identification more than 10 years ago, innate lymphoid cells (ILCs) have emerged as denizens of an immune realm parallel to that of T cells. Here I highlight basic similarities shared by all and underscore features related to development, tissue residency and regulation that distinguish ILCs from T cells. I further discuss the potential of ILCs as promising targets for therapeutic intervention in human diseases. © 2022. The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.