Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

The implementation of self-optimizing flow reactors has been mostly limited to model reactions or known synthesis routes. In this work, a self-optimizing flow photochemistry platform is used to develop an original synthesis of the bioactive fragment of Salbutamol and derivatives. The key photochemical steps for the construction of the aryl vicinyl amino alcohol moiety consist of a C-C bond forming reaction followed by an unprecedented, high yielding (>80 %), benzylic oxidative cyclization. © 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.


Romaric Gérardy, Anirudh M K Nambiar, Travis Hart, Prajwal T Mahesh, Klavs F Jensen. Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self-Optimizing Flow Chemistry Platform. Chemistry (Weinheim an der Bergstrasse, Germany). 2022 Aug 01;28(43):e202201385

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 35570196

View Full Text