β-1,6-Glucan From Pleurotus eryngii Modulates the Immunity and Gut Microbiota.

Xue Wang, Yunhe Qu, Yuan Wang, Xiang Wang, Jialei Xu, Hailing Zhao, Donglin Zheng, Lin Sun, Guihua Tai, Yifa Zhou, Hairong Cheng

Frontiers in immunology 2022

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Polysaccharides from Pleurotus eryngii exhibit a variety of biological activities. Here, we obtained a homogeneous branched β-1,6-glucan (APEP-A-b) from the fruiting bodies of P. eryngii and investigated its effect on immunity and gut microbiota. Our results showed that APEP-A-b significantly increases splenic lymphocyte proliferation, NK cell activity and phagocytic capacity of peritoneal cavity phagocytes. Furthermore, we found that the proportion of CD4+ and CD8+ T cells in lamina propria are significantly increased upon APEP-A-b treatment. Additionally, APEP-A-b supplementation demonstrated pronounced changes in microbiota reflected in promotion of relative abundances of species in the Lachnospiraceae and Rikenellaceae families. Consistently, APEP-A-b significantly increased the concentration of acetic and butyric acid in cecum contents. Overall, our results suggest that β-1,6-glucan from P. eryngii might enhance immunity by modulating microbiota. These results are important for the processing and product development of P. eryngii derived polysaccharides. Copyright © 2022 Wang, Qu, Wang, Wang, Xu, Zhao, Zheng, Sun, Tai, Zhou and Cheng.

Citation

Xue Wang, Yunhe Qu, Yuan Wang, Xiang Wang, Jialei Xu, Hailing Zhao, Donglin Zheng, Lin Sun, Guihua Tai, Yifa Zhou, Hairong Cheng. β-1,6-Glucan From Pleurotus eryngii Modulates the Immunity and Gut Microbiota. Frontiers in immunology. 2022;13:859923