Regulation of wound healing and fibrosis by galectins.

Galectins are a family of proteins with at least one carbohydrate-recognition domain. Galectins are present in various tissues and organs and participate in different physiological and pathological molecular reactions in vivo. Wound healing is the basic process of traumatic disease recovery. Wound healing involves three overlapping stages: inflammation, proliferation, and remodelling. Furthermore, a comparison of wound healing with the tumour microenvironment revealed that galectin plays a key role in the wound healing process. The current review describes the role of galectin in inflammation, angiogenesis, re-epithelialisation, and fibrous scar formation and evaluates its potential as a therapeutic drug for wounds. © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Citation

Dong Yu, Ming Bu, Ping Yu, Yaping Li, Yang Chong. Regulation of wound healing and fibrosis by galectins. Journal of molecular medicine (Berlin, Germany). 2022 Jun;100(6):861-874

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PMID: 35589840

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