Vaccines and Immunoinformatics for Vaccine Design.

Shikha Joon, Rajeev K Singla, Bairong Shen

Advances in experimental medicine and biology 2022

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The host immune system recognizes and responds to the selective antigens or epitopes (immunome) of the intruding pathogen over an entire organism. The immune response so generated is ample to confer the desired immunity and protection to the host. This led to the conception of immunome-derived vaccines that exploit selective genome-derived antigens or epitopes from the pathogen's immunome and not its entire genome or proteome. These are designed to elicit the required immune response and confer protection against future invasions by the same pathogen. Immunoinformatics through its epitope mapping tools allows direct selection of antigens from a pathogen's genome or proteome, which is critical for the generation of an effective vaccine. This paved way for novel vaccine design strategies based on the mapped epitopes for translational applications that includes prophylactic, therapeutic, and personalized vaccines. In this chapter, various Immunoinformatics tools for epitope mapping are presented along with their applications. The methodology for immunoinformatics-assisted vaccine design is also outlined. © 2022. The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

Citation

Shikha Joon, Rajeev K Singla, Bairong Shen. Vaccines and Immunoinformatics for Vaccine Design. Advances in experimental medicine and biology. 2022;1368:95-110