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In the past decade, the incidence of recurrent pregnancy loss (RPL) has increased significantly, and immunological disorders have been considered as one of the possible causes contributing to RPL. The presence of antinuclear antibodies (ANAs) is regarded as a typical antibody of autoimmunity. However, the relationship between the presence of ANAs and RPL, the underlying mechanism, and the possible role of immunotherapy is still controversial. The aim of this mini review is to assess the association between ANAs and RPL and the effects of immunotherapy on pregnancy outcomes in women with positive ANAs and a history of RPL from the available data and to provide a relevant reference basis for clinical application in this group of women. Copyright © 2022 Liu, Guo, Liao, Liu, Zhu and Chen.


Ting Liu, Xi Guo, Ying Liao, Yingyu Liu, Yuanfang Zhu, Xiaoyan Chen. Correlation Between the Presence of Antinuclear Antibodies and Recurrent Pregnancy Loss: A Mini Review. Frontiers in endocrinology. 2022;13:873286

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PMID: 35600596

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