HATs meet structural biology.

Josep Rullo-Tubau, Paola Bartoccioni, Oscar Llorca, Ekaitz Errasti-Murugarren, Manuel Palacín

Current opinion in structural biology 2022 Jun

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Heteromeric amino acid transporters (HATs) are one of the ten types of amino acid transporters present in the human body. Growing interest in the pathophysiological role of this group of transporters in rare and complex diseases and cancer has brought about the recent resolution of various structures of human HATs and bacterial homologues at atomic level. This knowledge sheds light on the mechanisms of transport used by these molecules. Here, we discuss the molecular bases underlying substrate specificity, binding asymmetry, and the impact of disease-causing mutations on transporter biogenesis and function. Copyright © 2022 Elsevier Ltd. All rights reserved.

Citation

Josep Rullo-Tubau, Paola Bartoccioni, Oscar Llorca, Ekaitz Errasti-Murugarren, Manuel Palacín. HATs meet structural biology. Current opinion in structural biology. 2022 Jun;74:102389