Glycoproteins of Capsosiphon fulvescens modulate synaptic clustering of PSD95 and prevent social isolation-induced cognitive decline in aged male rats.

Social isolation and loneliness inducing cognitive decline are serious health problems in the elderly. Although the hydrophilic glycoproteins of Capsosiphon fulvescens (Cf-hGP) prevent aging-induced cognitive impairment, its effects on social isolation-induced cognitive dysfunction are unclear. This study investigated the efficacy of Cf-hGP against cognitive dysfunction in aged rats and delineated its underlying mechanisms. The oral administration of Cf-hGP (15 mg/kg/d, 4 weeks) reversed the social isolation-induced decreases in phosphorylation of extracellular signal‑regulated protein kinase 1/2 (ERK1/2), postsynaptic density protein 95, and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor subunit 1 and increased expression of metabotropic glutamate receptor 5 in the synaptosome of the dorsal hippocampus. Furthermore, Cf-hGP prevented social isolation-induced spatial memory impairment, and its effects were attenuated by inhibition of ERK1/2 or deglycosylation of Cf-hGP. Cf-hGP-induced clustering of ERK1/2-mediated postsynaptic density protein 95 in the dorsal hippocampus improves memory formation in socially isolated aged rats, and protein glycosylation contributes to enhancing the Cf-hGP effect. Copyright © 2022. Published by Elsevier Inc.

Citation

Jeong Hwan Oh, Youn Hee Choi, Taek-Jeong Nam. Glycoproteins of Capsosiphon fulvescens modulate synaptic clustering of PSD95 and prevent social isolation-induced cognitive decline in aged male rats. The Journal of nutritional biochemistry. 2022 Sep;107:109054

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PMID: 35609859

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