miR-188-3p targets skeletal endothelium coupling of angiogenesis and osteogenesis during ageing.

Cell death & disease 2022 May 25

filter terms:

A specific bone capillary subtype, namely type H vessels, with high expression of CD31 and endomucin, was shown to couple angiogenesis and osteogenesis recently. The number of type H vessels in bone tissue declines with age, and the underlying mechanism for this reduction is unclear. Here, we report that microRNA-188-3p (miR-188-3p) involves this process. miRNA-188-3p expression is upregulated in skeletal endothelium and negatively regulates the formation of type H vessels during ageing. Mice with depletion of miR-188 showed an alleviated age-related decline in type H vessels. In contrast, endothelial-specific overexpression of miR-188-3p reduced the number of type H vessels, leading to decreased bone mass and delayed bone regeneration. Mechanistically, we found that miR-188 inhibits type H vessel formation by directly targeting integrin β3 in endothelial cells. Our findings indicate that miR-188-3p is a key regulator of type H vessel formation and may be a potential therapeutic target for preventing bone loss and accelerating bone regeneration. © 2022. The Author(s).

Citation

Wen-Zhen He, Mi Yang, Yangzi Jiang, Chen He, Yu-Chen Sun, Ling Liu, Mei Huang, Yu-Rui Jiao, Kai-Xuan Chen, Jing Hou, Min Huang, Yi-Li Xu, Xu Feng, Ya Liu, Qi Guo, Hui Peng, Yan Huang, Tian Su, Ye Xiao, Yusheng Li, Chao Zeng, Guanghua Lei, Xiang-Hang Luo, Chang-Jun Li. miR-188-3p targets skeletal endothelium coupling of angiogenesis and osteogenesis during ageing. Cell death & disease. 2022 May 25;13(5):494