Organophotoredox-catalyzed cyanoalkylation of 1,4-quinones.

Arun D Kulthe, Sunidhi Jaiswal, Durga Golagani, Prathama S Mainkar, Srirama Murthy Akondi

Organic & biomolecular chemistry 2022 Jun 08

filter terms:

A visible-light-induced metal-free cyanoalkylation of 1,4-quinones under mild and redox-neutral conditions is described. This reaction proceeds at room temperature without the need of extra base or additive and is suitable for a variety of 1,4-quinones and differently substituted cyclobutanone oxime esters. Further transformation of cyano functionality to tetrazole and amine has also been demonstrated to showcase the advantage of this method to prepare drug-like molecules.

Citation

Arun D Kulthe, Sunidhi Jaiswal, Durga Golagani, Prathama S Mainkar, Srirama Murthy Akondi. Organophotoredox-catalyzed cyanoalkylation of 1,4-quinones. Organic & biomolecular chemistry. 2022 Jun 08;20(22):4534-4538