The translational challenge in Chagas disease drug development.

Jadel M Kratz, Karolina R Gonçalves, Lavínia Md Romera, Carolina Borsoi Moraes, Paula Bittencourt-Cunha, Sergio Schenkman, Eric Chatelain, Sergio Sosa-Estani

Memorias do Instituto Oswaldo Cruz 2022

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Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. There is an urgent need for safe, effective, and accessible new treatments since the currently approved drugs have serious limitations. Drug development for Chagas disease has historically been hampered by the complexity of the disease, critical knowledge gaps, and lack of coordinated R&D efforts. This review covers some of the translational challenges associated with the progression of new chemical entities from preclinical to clinical phases of development, and discusses how recent technological advances might allow the research community to answer key questions relevant to the disease and to overcome hurdles in R&D for Chagas disease.

Citation

Jadel M Kratz, Karolina R Gonçalves, Lavínia Md Romera, Carolina Borsoi Moraes, Paula Bittencourt-Cunha, Sergio Schenkman, Eric Chatelain, Sergio Sosa-Estani. The translational challenge in Chagas disease drug development. Memorias do Instituto Oswaldo Cruz. 2022;117:e200501