Cytokine Production in Whole Blood Cells Culture of Patients with Alcohol Dependence and Autologous Plasma Oxidative Stress Markers.

T P Vetlugina, V D Prokopieva, E V Epimakhova, A S Boiko, V B Nikitina, N A Bokhan

Bulletin of experimental biology and medicine 2022 May

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We studied spontaneous production of a spectrum of proinflammatory cytokines by cultured whole blood cells from men with alcohol dependence at the stage of withdrawal syndrome and oxidative stress markers (carbonylated proteins and TBA-reactive substances) in the plasma of these blood samples. Enhanced production of cytokines by blood cells and increased concentrations of oxidative stress markers in the autologous plasma were revealed in comparison with the corresponding parameters in the control (blood from healthy men). Direct correlations were found between the levels of spontaneous cytokine production by blood cells from subjects with alcohol dependence and the concentration of oxidized proteins and lipids in autologous plasma. © 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Citation

T P Vetlugina, V D Prokopieva, E V Epimakhova, A S Boiko, V B Nikitina, N A Bokhan. Cytokine Production in Whole Blood Cells Culture of Patients with Alcohol Dependence and Autologous Plasma Oxidative Stress Markers. Bulletin of experimental biology and medicine. 2022 May;173(1):151-154