Azole-Directed Cobalt-Catalyzed Asymmetric Hydrogenation of Alkenes.

The azole-directed cobalt-catalyzed asymmetric hydrogenation of alkenes has been developed with high efficiency. With this approach, chiral pyrazole compounds were obtained in quantitative yields and excellent enantioselectivities (up to 99 % ee) under mild conditions, and the hydrogenation was conducted on a gram scale with up to 2000 TON. Several useful applications were demonstrated including the convenient introduction of β-chirality to a drug intermediate containing an azole ring. © 2022 Wiley-VCH GmbH.

Citation

Yue Jin, Yashi Zou, Yanhua Hu, Yunxi Han, Zhenfeng Zhang, Wanbin Zhang. Azole-Directed Cobalt-Catalyzed Asymmetric Hydrogenation of Alkenes. Chemistry (Weinheim an der Bergstrasse, Germany). 2022 Aug 04;28(44):e202201517

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PMID: 35622378

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