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Improper hydration habits are commonly disregarded as a risk factor for the development of chronic diseases. Consuming an intake of water below recommendations (underhydration) in addition to the substitution of sugar-sweetened beverages (SSB) for water are habits deeply ingrained in several countries. This behavior is due to voluntary and involuntary dehydration; and because young children are exposed to SSB, the preference for a sweet taste is profoundly implanted in the brain. Underhydration and SSB intake lead to mild hyperosmolarity, which stimulates biologic processes, such as the stimulation of vasopressin and the polyol-fructose pathway, which restore osmolarity to normal but at the expense of the continued activation of these biological systems. Unfortunately, chronic activation of the vasopressin and polyol-fructose pathways has been shown to mediate many diseases, such as obesity, diabetes, metabolic syndrome, chronic kidney disease, and cardiovascular disease. It is therefore urgent that we encourage educational and promotional campaigns that promote the evaluation of personal hydration status, a greater intake of potable water, and a reduction or complete halting of the drinking of SSB.


Richard J Johnson, Fernando E García-Arroyo, Guillermo Gonzaga-Sánchez, Kevin A Vélez-Orozco, Yamnia Quetzal Álvarez-Álvarez, Omar Emiliano Aparicio-Trejo, Edilia Tapia, Horacio Osorio-Alonso, Ana Andrés-Hernando, Takahiko Nakagawa, Masanari Kuwabara, Mehmet Kanbay, Miguel A Lanaspa, Laura Gabriela Sánchez-Lozada. Current Hydration Habits: The Disregarded Factor for the Development of Renal and Cardiometabolic Diseases. Nutrients. 2022 May 15;14(10)

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PMID: 35631211

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