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It is important to determine the clinical significance of non-human leukocyte antigen (HLA) antibodies and their association with antibody-mediated rejection (ABMR) of kidney allografts. We collected post-transplant sera from 68 ABMR patients, 67 T-cell mediated rejection (TCMR) patients, and 83 control subjects without rejection, and determined the titers of 39 non-HLA antibodies including antibodies for angiotensin II receptor type I and MICA. We compared all these non-HLA antibody titers among the study groups. Then, we investigated their association with the risk of death-censored graft failure in ABMR cases. Among the antibodies evaluated, anti-collagen type I (p = 0.001) and type III (p < 0.001) antibody titers were significantly higher in ABMR cases than in both TCMR cases and no-rejection controls. Both anti-collagen type I [per 1 standard deviation (SD), adjusted odds ratio (OR), 11.72 (2.73-76.30)] and type III [per 1 SD, adjusted OR, 6.22 (1.91-31.75)] antibodies were significantly associated with the presence of ABMR. Among ABMR cases, a higher level of anti-collagen type I [per 1 SD, adjusted hazard ratio (HR), 1.90 (1.32-2.75)] or type III per 1 SD, [adjusted HR, 1.57 (1.15-2.16)] antibody was associated with a higher risk of death-censored graft failure. In conclusion, post-transplant anti-collagen type I and type III antibodies may be novel non-HLA antibodies related to ABMR of kidney allografts. Copyright © 2022 Park, Yang, Kim, Cho, Yang, Min, Ha, Jeong, Bhoo, Kim, Kim, Oh, Joo, Kim, Moon, Song and Lee.


Sehoon Park, Seung-Hee Yang, Jiyeon Kim, Semin Cho, Jaeseok Yang, Sang-Il Min, Jongwon Ha, Chang Wook Jeong, Seong Hee Bhoo, Yong Chul Kim, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Kyung Chul Moon, Eun Young Song, Hajeong Lee. Clinical Significances of Anti-Collagen Type I and Type III Antibodies in Antibody-Mediated Rejection. Transplant international : official journal of the European Society for Organ Transplantation. 2022;35:10099

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PMID: 35634584

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