Structural insights into ORF10 recognition by ZYG11B.

Bing Zhang, Yao Li, Qiqi Feng, Lili Song, Cheng Dong, Xiaojie Yan

Biochemical and biophysical research communications 2022 Aug 06

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Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a major threat to human health. As a unique putative protein of SARS-CoV-2, the N-terminus of ORF10 can be recognized by ZYG11B, a substrate receptor of the Cullin 2-RING E3 ubiquitin ligase (CRL2). Here we elucidated recognition mechanism of ORF10 N-terminus by ZYG11B through presenting the crystal structure of ZYG11B bound to ORF10 N-terminal peptide. Our work expands the current understanding of ORF10 interaction with ZYG11B, and may also inspire the development of novel therapies for COVID-19. Copyright © 2022 Elsevier Inc. All rights reserved.

Citation

Bing Zhang, Yao Li, Qiqi Feng, Lili Song, Cheng Dong, Xiaojie Yan. Structural insights into ORF10 recognition by ZYG11B. Biochemical and biophysical research communications. 2022 Aug 06;616:14-18