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After more than 20 years of trials, a practical scalable approach to fluoro-substituted bicyclo[1.1.1]pentanes (F-BCPs) has been developed. The physicochemical properties of the F-BCPs have been studied, and the core was incorporated into the structure of the anti-inflammatory drug Flurbiprofen in place of the fluorophenyl ring. © 2022 The Authors. Published by Wiley-VCH GmbH.

Citation

Roman Bychek, Pavel K Mykhailiuk. A Practical and Scalable Approach to Fluoro-Substituted Bicyclo[1.1.1]pentanes. Angewandte Chemie (International ed. in English). 2022 Jul 18;61(29):e202205103

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PMID: 35638404

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