MicroRNAs as therapeutic targets in cardiovascular disease.

Bernhard Laggerbauer, Stefan Engelhardt

The Journal of clinical investigation 2022 Jun 01

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The discovery of microRNAs and their role in diseases was a breakthrough that inspired research into microRNAs as drug targets. Cardiovascular diseases are an area in which limitations of conventional pharmacotherapy are highly apparent and where microRNA-based drugs have appreciably progressed into preclinical and clinical testing. In this Review, we summarize the current state of microRNAs as therapeutic targets in the cardiovascular system. We report recent advances in the identification and characterization of microRNAs, their manipulation and clinical translation, and discuss challenges and perspectives toward clinical application.

Citation

Bernhard Laggerbauer, Stefan Engelhardt. MicroRNAs as therapeutic targets in cardiovascular disease. The Journal of clinical investigation. 2022 Jun 01;132(11)