Oxygenases as Powerful Weapons in the Microbial Degradation of Pesticides.

Minggen Cheng, Dian Chen, Rebecca E Parales, Jiandong Jiang

Annual review of microbiology 2022 Sep 08

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Oxygenases, which catalyze the reductive activation of O2 and incorporation of oxygen atoms into substrates, are widely distributed in aerobes. They function by switching the redox states of essential cofactors that include flavin, heme iron, Rieske non-heme iron, and Fe(II)/α-ketoglutarate. This review summarizes the catalytic features of flavin-dependent monooxygenases, heme iron-dependent cytochrome P450 monooxygenases, Rieske non-heme iron-dependent oxygenases, Fe(II)/α-ketoglutarate-dependent dioxygenases, and ring-cleavage dioxygenases, which are commonly involved in pesticide degradation. Heteroatom release (hydroxylation-coupled hetero group release), aromatic/heterocyclic ring hydroxylation to form ring-cleavage substrates, and ring cleavage are the main chemical fates of pesticides catalyzed by these oxygenases. The diversity of oxygenases, specificities for electron transport components, and potential applications of oxygenases are also discussed. This article summarizes our current understanding of the catalytic mechanisms of oxygenases and a framework for distinguishing the roles of oxygenases in pesticide degradation.

Citation

Minggen Cheng, Dian Chen, Rebecca E Parales, Jiandong Jiang. Oxygenases as Powerful Weapons in the Microbial Degradation of Pesticides. Annual review of microbiology. 2022 Sep 08;76:325-348