Transcription factor networks in trophoblast development.

Henrieta Papuchova, Paulina A Latos

Cellular and molecular life sciences : CMLS 2022 Jun 03

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The placenta sustains embryonic development and is critical for a successful pregnancy outcome. It provides the site of exchange between the mother and the embryo, has immunological functions and is a vital endocrine organ. To perform these diverse roles, the placenta comprises highly specialized trophoblast cell types, including syncytiotrophoblast and extravillous trophoblast. The coordinated actions of transcription factors (TFs) regulate their emergence during development, subsequent specialization, and identity. These TFs integrate diverse signaling cues, form TF networks, associate with chromatin remodeling and modifying factors, and collectively determine the cell type-specific characteristics. Here, we summarize the general properties of TFs, provide an overview of TFs involved in the development and function of the human trophoblast, and address similarities and differences to their murine orthologs. In addition, we discuss how the recent establishment of human in vitro models combined with -omics approaches propel our knowledge and transform the human trophoblast field. © 2022. The Author(s).

Citation

Henrieta Papuchova, Paulina A Latos. Transcription factor networks in trophoblast development. Cellular and molecular life sciences : CMLS. 2022 Jun 03;79(6):337