Role and mechanism of BMP4 in bone, craniofacial, and tooth development.

Yuer Ye, Zhiwei Jiang, Yiqi Pan, Guoli Yang, Ying Wang

Archives of oral biology 2022 Aug

filter terms:

This review aimed to present an overview of the effect of bone morphogenetic protein 4 (BMP4) on craniofacial and skeletal development, particularly the specific role of BMP4 in tooth development. The search for this narrative review was conducted in PubMed, Web of Science, Embase, and ScienceDirect using relevant keywords, including checking reference lists of journal articles by hand searching. Mutations or deletions of BMP4 cause tissue development defects in mice and humans, such as fragile bone, craniofacial deformity, cleft lip and palate, tooth development stagnation, and abnormal structure. BMP4 is a reliable and vital candidate to regulate the development of bones, craniofacies, and teeth. It also has high clinical application potential. Copyright © 2022 Elsevier Ltd. All rights reserved.

Citation

Yuer Ye, Zhiwei Jiang, Yiqi Pan, Guoli Yang, Ying Wang. Role and mechanism of BMP4 in bone, craniofacial, and tooth development. Archives of oral biology. 2022 Aug;140:105465