WASP family proteins: Molecular mechanisms and implications in human disease.

Daniel A Kramer, Hannah K Piper, Baoyu Chen

European journal of cell biology 2022 Jun-Aug

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Proteins of the Wiskott-Aldrich syndrome protein (WASP) family play a central role in regulating actin cytoskeletal dynamics in a wide range of cellular processes. Genetic mutations or misregulation of these proteins are tightly associated with many diseases. The WASP-family proteins act by transmitting various upstream signals to their conserved WH2-Central-Acidic (WCA) peptide sequence at the C-terminus, which in turn binds to the Arp2/3 complex to stimulate the formation of branched actin networks at membranes. Despite this common feature, the regulatory mechanisms and cellular functions of distinct WASP-family proteins are very different. Here, we summarize and clarify our current understanding of WASP-family proteins and how disruption of their functions is related to human disease. Copyright © 2022 The Authors. Published by Elsevier GmbH.. All rights reserved.

Citation

Daniel A Kramer, Hannah K Piper, Baoyu Chen. WASP family proteins: Molecular mechanisms and implications in human disease. European journal of cell biology. 2022 Jun-Aug;101(3):151244