Mass spectrometry-based retina proteomics.

Laszlo Prokai, Khadiza Zaman, Katalin Prokai-Tatrai

Mass spectrometry reviews 2023 May

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A subfield of neuroproteomics, retina proteomics has experienced a transformative growth since its inception due to methodological advances in enabling chemical, biochemical, and molecular biology techniques. This review focuses on mass spectrometry's contributions to facilitate mammalian and avian retina proteomics to catalog and quantify retinal protein expressions, determine their posttranslational modifications, as well as its applications to study the proteome of the retina in the context of biology, health and diseases, and therapy developments. © 2022 John Wiley & Sons Ltd.