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Bactopterin is a novel pterin occurring in bacterial molybdoenzymes as the organic portion of the molybdenum cofactor. Its structure is investigated here. The compound contains a single pterin ring and carries a side chain at carbon atom 6 of the pterin nucleus as indicated by the formation of pterin-6-carboxylic acid upon alkaline permanganate oxidation. Studies with phosphate-cleaving enzymes revealed the presence of two monophosphoric acid monoesters. The affinity of reduced bactopterin for thiol-Sepharose points to the presence of thiol(s) in active bactopterin.


B Krüger, O Meyer. Structural elements of bactopterin from Pseudomonas carboxydoflava carbon monoxide dehydrogenase. Biochimica et biophysica acta. 1987 Apr 30;912(3):357-64

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PMID: 3567206

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