Multicomponent Assembly of Trisubstituted Imidazoles and Their Photochemical Cyclization into Fused Polyheterocyclic Scaffolds.

A straightforward route to a large and diverse library of trisubstituted imidazoles was established via a three-component reaction of 2-oxoaldehydes, 1,3-dicarbonyl compounds, and acyclic nitrogen bis-nucleophiles. The obtained products were subsequently explored in a photochemical cyclization yielding a variety of imidazole-fused polycyclic compounds.

Citation

Diana Gapanenok, Azat Makhmet, Anatoly A Peshkov, Darya Smirnova, Niyaz Amire, Vsevolod A Peshkov, Darya Spiridonova, Dmitry Dar'in, Saeed Balalaie, Mikhail Krasavin. Multicomponent Assembly of Trisubstituted Imidazoles and Their Photochemical Cyclization into Fused Polyheterocyclic Scaffolds. The Journal of organic chemistry. 2022 Jun 17;87(12):7838-7851

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PMID: 35675099

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