Two new isoflavones from the roots of Sophora tonkinensis.

Two new isoflavones (1 and 2), as well as eight known ones were isolated from the roots of Sophora tonkinensis Gagnep. Compound 1 represents an unprecedented polymerization pattern constructed by isoflavone and cytisine. Their structures were elucidated by comprehensive spectroscopic data analysis, combined with ECD calculations. Compound 1 displayed significant anti-tobacco mosaic virus (TMV) activity compared with the positive control ningnanmycin. Moreover, compound 6 exhibited potent α-glucosidase inhibitory activity with IC50 value of 47.4 mg/L.

Citation

Dao-Jun Chen, Shuang Yuan, Peng Zhang, Qiao An, Ji-Bin Zou, Chun-Mao Yuan, Li-Hua Zhao, Zhan-Xing Hu, Xiao-Jiang Hao. Two new isoflavones from the roots of Sophora tonkinensis. Journal of Asian natural products research. 2023 Feb;25(2):163-170

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PMID: 35675145

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