Correlation Engine 2.0
Clear Search sequence regions

  • africa (1)
  • apicoplast (3)
  • genomes (1)
  • haemosporida (1)
  • humans (1)
  • lemur (8)
  • malaria (4)
  • malaria plasmodium falciparum (1)
  • parasites (6)
  • plasmodium (4)
  • primates (1)
  • spp (1)
  • taxa (1)
  • tree (1)
  • Sizes of these terms reflect their relevance to your search.

    Among the primate malaria parasites, those found in lemurs have been neglected. Here, six Plasmodium lineages were detected in 169 lemurs. Nearly complete mitochondrial genomes (mtDNA, ≈6Kb) and apicoplast loci (≈6Kb) were obtained from these parasites and other Haemosporida species. Plasmodium spp. in lemurs are a diverse clade that shares a common ancestor with other primate parasites from continental Africa. Time-trees for the mtDNA were estimated under different scenarios, and the origin of the lemur clade coincides with the proposed time of their host species' most recent common ancestor (Lemuridae-Indriidae). A time tree with fewer taxa was estimated with mtDNA + Apicoplast loci. Those time estimates overlapped but were younger and had narrower credibility intervals than those from mtDNA alone. Importantly, the mtDNA + Apicoplast estimates that the clade including the most lethal malaria parasite in humans, Plasmodium falciparum, may have originated with Homininae (African apes). Finally, the phylogenetic congruence of the lemurs and their parasites was explored. A statistically significant scenario identified four cospeciation, two duplications, four transfer (host-switches), and zero loss events. Thus, the parasite species sampled in lemurs seem to be radiating with their hosts. Copyright © 2022 Elsevier Inc. All rights reserved.


    M Andreína Pacheco, Randall E Junge, Adithyan Menon, Jon McRoberts, Gediminas Valkiūnas, Ananias A Escalante. The evolution of primate malaria parasites: A study on the origin and diversification of Plasmodium in lemurs. Molecular phylogenetics and evolution. 2022 Sep;174:107551

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 35690381

    View Full Text