Enoxacin-based derivatives: antimicrobial and antibiofilm agent: a biology-oriented drug synthesis (BIODS) approach.

Ayaz Ahmed, Anum Khalid Khan, Aneela Karim, Rakhshinda Siddiqui, Rafaila Rafique, Syed Abid Ali, Mehwish Solangi, Muhammad Taha, Khalid Mohammed Khan

Future medicinal chemistry 2022 Jul

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Background: To find alternative molecules against Klebsiella pneumonia, Proteus mirabilis and methicillin-resistant Staphylococcus aureus, new enoxacin derivatives were synthesized and screened. Methods: All derivatives exhibited promising antibacterial activities as compared to standard enoxacin (2 μg/ml) and standard cefixime (82 μg/ml). Compounds 2, 3 and 5 significantly downregulated the gene expression of biofilm-forming genes. Conclusion: Based on our results, these molecules may serve as potential drug candidates to cure several bacterial infections in the future.

Citation

Ayaz Ahmed, Anum Khalid Khan, Aneela Karim, Rakhshinda Siddiqui, Rafaila Rafique, Syed Abid Ali, Mehwish Solangi, Muhammad Taha, Khalid Mohammed Khan. Enoxacin-based derivatives: antimicrobial and antibiofilm agent: a biology-oriented drug synthesis (BIODS) approach. Future medicinal chemistry. 2022 Jul;14(13):947-962