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Wang et al. report in this issue (2022. J. Cell Biol. that the SARS-CoV-2 protein ORF10 increases the activity of the E3 ligase CUL2ZYG11B, leading to the degradation of multiple ciliary proteins. The resulting loss of cilia may facilitate the spread of SARS-CoV-2 in the respiratory tree. © 2022 Fonseca and Chakrabarti.


Barbara F Fonseca, Lisa A Chakrabarti. A close shave: How SARS-CoV-2 induces the loss of cilia. The Journal of cell biology. 2022 Jul 04;221(7)

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PMID: 35695891

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