Multi-neurotransmitter regulation of neural firing via coincidence of parallel G-protein signals.

Burak Uzay, Ege T Kavalali

Cell calcium 2022 Jul

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Neurotransmitter activation of G protein-coupled receptors differentially modulate neural information transfer and activity. A recent study by Tian and colleagues have identified that activation of two ion channels, Transient Receptor Potential Channel 4 (TRPC4) and G protein-coupled inward rectifier K+ (GIRK) modulate action potential firing upon co-activation Gi/o and Gq by co-released neurotransmitters. Here, we discuss these results suggesting a nonlinear interaction of coincidental Gi/o and Gq/11 activation that yields discernible neuronal activity patterns during neurotransmission. Copyright © 2022 Elsevier Ltd. All rights reserved.

Citation

Burak Uzay, Ege T Kavalali. Multi-neurotransmitter regulation of neural firing via coincidence of parallel G-protein signals. Cell calcium. 2022 Jul;105:102611