A complex puzzle: Regulation of SLFN12 RNase activity by phosphorylation.

PDE3A-SLFN12 complex formation activates the SLFN12 RNase, but the biochemical details of RNase activation remain mysterious. In this issue of Cell Chemical Biology, Yan and colleagues report that two phosphoserines on SLFN12 are dephosphorylated in response to PDE3A binding, and this dephosphorylation is required for activation of the SLFN12 RNase. Copyright © 2022 Elsevier Ltd. All rights reserved.

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Heidi Greulich. A complex puzzle: Regulation of SLFN12 RNase activity by phosphorylation. Cell chemical biology. 2022 Jun 16;29(6):925-927

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PMID: 35714590

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