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In this work, a bioassay-guided fractionation strategy was used to isolate 26 phenolic compounds from the ethyl acetate partition of an ethanol extract of the aerial parts of Glycyrrhiza uralensis Fisch. ex DC. Among them, 8 prenylated phenolic compounds (glycyuralins Q-X) were described for the first time. The two enantiomers of glycyuralin Q were purified and their absolute configurations were established by ECD spectral calculations. (1″R, 2″S)-glycyuralin Q and (1″S, 2″R)-glycyuralin Q showed significant inhibitory activities against SARS-CoV-2 virus proteases 3CLpro with IC50 values of 1.5 ± 1.0 and 4.0 ± 0.3 μM, and PLpro with IC50 values of 2.4 ± 0.2 and 1.9 ± 0.1 μM, respectively. Four compounds showed potent cytotoxic activities against A549, Huh-7, and HepG2 human cancer cells with IC50 values ranging from 0.5 to 2.5 μM. Copyright © 2022 Elsevier Ltd. All rights reserved.


Aobulikasimu Hasan, Meng Zhang, Zhan-Peng Shang, Yang Yi, Yi Kuang, Rong Yu, Jing-Jing Fan, Yu-Xi Huang, Dilaram Nijat, Xue Qiao, Min Ye. Bioactive prenylated phenolic compounds from the aerial parts of Glycyrrhiza uralensis. Phytochemistry. 2022 Sep;201:113284

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PMID: 35714736

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