Multifunctional Electrospun Textiles for Wound Healing.

Guopu Chen, Jie Hu, Zhiwu Hong, Gefei Wang, Zhiming Wang, Canwen Chen, Jinjian Huang, Xiuwen Wu, Jianan Ren

Journal of biomedical nanotechnology 2022 Mar 01

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The novel multifunctional electrospun textiles were fabricated by incorporating sheet-like kaolinite and silver nanoparticles (AgNps) into a polyurethane (PU) textile by using electrostatic spinning to promote wound-healing process. Threedimensional network of PU electrospun textiles offered an appropriate framework for loading kaolinite nanosheets and AgNps. Moreover, the kaolinite nanosheets healed bleeding wounds by accelerating plasma absorption, increasing blood cell concentrations, and stimulating coagulation factors. Furthermore, the AgNps killed microbes by destroying the cell membrane, while the deleterious effects were controlled by incorporation into the electrospun textile. The therapeutic effects of multifunctional electrospun textile in treating full-thickness abdominal wall defect were explored. The wound healing process could be accelerated via the textile by restoring the abdominal physiological environment, reducing the inflammatory response, and promoting collagen deposition, angiogenesis, and epithelization.

Citation

Guopu Chen, Jie Hu, Zhiwu Hong, Gefei Wang, Zhiming Wang, Canwen Chen, Jinjian Huang, Xiuwen Wu, Jianan Ren. Multifunctional Electrospun Textiles for Wound Healing. Journal of biomedical nanotechnology. 2022 Mar 01;18(3):796-806