Drug-induced Liver Injury in Pediatrics.

Fernanda Monge-Urrea, Ericka Montijo-Barrios

Journal of pediatric gastroenterology and nutrition 2022 Oct 01

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Drug-induced liver injury (DILI) is a rare, underdiagnosed cause of liver disease in children. The incidence of DILI in the pediatric population is unknown but it represents around 10% of all DILI cases. The most common hepatotoxic drugs in children are antibiotics and antiepileptics. DILI is classified as intrinsic or idiosyncratic and it presents mostly with 2 patterns of injury: hepatocellular or cholestatic. Diagnosis can be done with help of the Roussel Uclaf Causality Assessment Method (RUCAM) casualty assessment. The mainstay of treatment is prompt withdrawal of the suspect drug. Copyright © 2022 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.

Citation

Fernanda Monge-Urrea, Ericka Montijo-Barrios. Drug-induced Liver Injury in Pediatrics. Journal of pediatric gastroenterology and nutrition. 2022 Oct 01;75(4):391-395