The role of IL-10 in kidney disease.

Wei Wei, Yibo Zhao, Yan Zhang, Heng Jin, Songtao Shou

International immunopharmacology 2022 Jul

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Kidney disease is a global health problem with high mortality and socioeconomic burden, including acute kidney injury (AKI), chronic kidney disease (CKD), diabetic nephropathy (DN),and lupus nephritis (LN). However, IL-10 is an anti-inflammatory factor. During severe infection in kidney disease, maintaining tissue homeostasis by inhibiting excessive inflammatory response, regulating immune suppression, delaying tissue fibrosis, and promoting tissue repair. Therefore, improving the pathogenesis and identifying effective therapeutic targets are significant for treating and diagnosing kidney diseases. Thus, the current review describes the structure and function of the IL-10 family and focuses on crucial role in kidney disease. We further discuss the regulatory mechanisms through which IL-10 is involved in kidney disease progression. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.