Rick W Dorn, Brendan J Wall, Sarah B Ference, Sean R Norris, Joseph W Lubach, Aaron J Rossini, Brett VanVeller
Organic letters 2022 Aug 12Differentiation of heterocyclic isomers by solution 1H, 13C, and 15N NMR spectroscopy is often challenging due to similarities in their spectroscopic signatures. Here, 13C{14N} solid-state NMR spectroscopy experiments are shown to operate as an "attached nitrogen test", where heterocyclic isomers are easy to distinguish based on one-dimensional nitrogen-filtered 13C solid-state NMR. We anticipate that these NMR experiments will facilitate the assignment of heterocyclic isomers during synthesis and natural product discovery.
Rick W Dorn, Brendan J Wall, Sarah B Ference, Sean R Norris, Joseph W Lubach, Aaron J Rossini, Brett VanVeller. Attached Nitrogen Test by 13C-14N Solid-State NMR Spectroscopy for the Structure Determination of Heterocyclic Isomers. Organic letters. 2022 Aug 12;24(31):5635-5640
PMID: 35731042
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