Postpartum Involution of Mouse Myometrium in Acute CCl4-Induced Hepatosis and Its Correction with Immobilized Hyaluronidase.

A P Nadeev, P G Madonov, E V Porotnikova, K A Koshlich, A V Kuznetsov, E V Ovsyanko, L Yu Kostina, D Ya Yakuba

Bulletin of experimental biology and medicine 2022 Jun

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We studied structural rearrangement of the myometrium of C57BL/6 mice during the postpartum period under conditions of acute toxic hepatosis induced by CCl4 injection and its correction with immobilized hyaluronidase. In contrast to physiological pregnancy, involution of the myometrium in mice under conditions of acute toxic hepatosis were not completed by the 10th day of the postpartum period. When toxic hepatosis was corrected with immobilized hyaluronidase, the main mechanism of postpartum involution of the mouse myometrium was clasmacytosis, the process of postpartum involution was significantly accelerated, but not completed by the 10th day, probably due to reduced vascularization of the myometrium. © 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Citation

A P Nadeev, P G Madonov, E V Porotnikova, K A Koshlich, A V Kuznetsov, E V Ovsyanko, L Yu Kostina, D Ya Yakuba. Postpartum Involution of Mouse Myometrium in Acute CCl4-Induced Hepatosis and Its Correction with Immobilized Hyaluronidase. Bulletin of experimental biology and medicine. 2022 Jun;173(2):265-269