Correlation Engine 2.0
Clear Search sequence regions

  • anguilla (3)
  • apoptosis (1)
  • dna repair (1)
  • lipid (1)
  • liver (1)
  • metal (1)
  • new caledonia (3)
  • nickel (6)
  • rivers (2)
  • target genes (1)
  • target proteins (1)
  • Sizes of these terms reflect their relevance to your search.

    New Caledonia is particularly affected by nickel open pit mining activities because of the presence of ultramafic soils rich in metals. The particles dispersed by atmospheric transport and soil erosion during the excavation of nickel end up by deposition or leaching in rivers where they may be bioaccumulated by organisms living downstream the mines. Despite alarming freshwater metals concentrations, no study investigated the level of their bioaccumulation in eels, and if high bioaccumulation levels occur, the potential consequences on their health. The aim of this study was to determine how eels Anguilla marmorata are impacted in situ by metals issued from mining activity by measuring: morphometric parameters; metal concentrations in tissues and organs and transcription levels of target genes encoding proteins involved in several metabolic key functions. Among organs, liver was found to be the most affected by mining with average nickel concentrations of 5.14 mg/kg versus 1.63 mg/kg for eels away from mines leading to dysregulation of numerous genes involved in oxidative stress, DNA repair, apoptosis, reproduction and both lipid and mitochondrial metabolisms. This study should allow us to define in an integrated way if metals released by mining activities influence metals bioaccumulation in eels and induce biological effects. Copyright © 2022 Elsevier B.V. All rights reserved.


    Ophélie Germande, Peggy Gunkel-Grillon, Yannick Dominique, Agnès Feurtet-Mazel, Emilie Bierque, Emilie Dassié, Guillemine Daffe, Fabien Pierron, Isabelle Baudrimont, Magalie Baudrimont. Impact of nickel mining in New Caledonia on marbled eels Anguilla marmorata. Journal of hazardous materials. 2022 Aug 15;436:129285

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 35739794

    View Full Text