Shigella "Osp"pression of innate immunity.

Skylar S Wright, Sivapriya Kailasan Vanaja

Cell 2022 Jun 23

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Interferons are potent antimicrobial effectors and thus an attractive target for pathogen interference. In this issue of Cell, Alphonse et al. reveal that the Shigella effectors OspC1 and OspC3 employ a surprising mechanism to block interferon signaling and attenuate antibacterial responses, thus securing their replicative niche. Copyright © 2022. Published by Elsevier Inc.