miR-590-5p: A double-edged sword in the oncogenesis process.

Tushar Singh Barwal, Neha Singh, Uttam Sharma, Sonali Bazala, Medha Rani, Alisha Behera, Ram Kumar Kumawat, Pawan Kumar, Vivek Uttam, Akanksha Khandelwal, Jyoti Barwal, Manju Jain, Aklank Jain

Cancer treatment and research communications 2022

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Accumulating evidence suggests the critical role of miR-590-5p in various aspects of cellular homeostasis, including cancer. Furthermore, we and others have recently demonstrated that miRNA-590-5p acts as an oncogene in some cancers while it acts as a tumor-suppressor in others. However, the role of miR-590-5p in oncogenesis is more complex, like a double-edged sword. Thus, this systematic review introduces the concept, mechanism, and biological function of miR-590-5p to resolve this apparent paradox. We have also described the involvement of miR-590-5p in crucial cancer-hallmarks processes like proliferation, invasion, metastasis, and chemo radioresistance. Finally, we have presented the possible genes/pathways targets of miR-590-5p through bioinformatics analysis. This review may help in designing better biomarkers and therapeutic targets for cancers. Copyright © 2022. Published by Elsevier Ltd.

Citation

Tushar Singh Barwal, Neha Singh, Uttam Sharma, Sonali Bazala, Medha Rani, Alisha Behera, Ram Kumar Kumawat, Pawan Kumar, Vivek Uttam, Akanksha Khandelwal, Jyoti Barwal, Manju Jain, Aklank Jain. miR-590-5p: A double-edged sword in the oncogenesis process. Cancer treatment and research communications. 2022;32:100593